Proton pump inhibitors are a group of medication that reduce the volume of acid in the stomach by blocking the enzyme in the wall of stomach that produces acid. They are the most potential inhibitors of acid secretion available today. PPIs are used for prevention and treatment of acid related condition such as:
• Dyspepsia
• Peptic ulcer
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome
Besides that, they can be used in combination with antibiotics for other condition,like to treat Helicobacter pylori bacteria that causing ulcers of the stomach.
Acid is produced by our stomach in order to help the body in digesting the food. Sometimes acid in certain condition can be over produced, this will irritate your stomach and causing ulcers. PPIs work by reducing the production of the acid in the stomach. They do this by inhibiting a system in the stomach called as proton pump. Proton pump is the one whose responsible in producing acid in the stomach.
Proton pump inhibitors are very similar in how they work, and there is no evidence that one is more effective than another. However, they are differ in how they’re broken down by the liver and their interactions with other drugs.
List of the prescription drugs belonging to PPIs are (generic name in parentheses):
1. Achipex (Rabeprazole)
2. Nexium (Esomeprazole)
3. Prevacid (Lansoprazole)
4. Prilosec (Omeprazole)
5. Protonix (Pantoprazole)
Proton pump inhibitors aren’t the only type of gastrointestinal medication. The other is H2 Blockers. They are similar in effect but different in their action. But PPIs are more popular and their drugs are among the most widely selling drugs in the world as a result of their outstanding efficacy and safety.
Some common side effects that could come out for a while:
• Headache
• Diarrhea
• Nausea
• Abdominal pain
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